George Snell shared the 1980 Nobel Prize in Physiology or Medicine for this pioneering work, which led to successful organ and tissue transplantation in humans and increased understanding of immune diseases. One such discovery in the 1940s was the MHC (major histocompatibility complex), a critical set of genes that determines the ability of our immune systems to respond to foreign antigens such as infectious viruses. Over the years, many Jackson researchers have been recognized for outstanding contributions to science. World-class research and scientific achievements are hallmarks of the Laboratory. Largely as a result of The Jackson Laboratory’s own research and its commitment to providing unique, quality resources to the community, the mouse has become the primary experimental system for mammalian genetics research. These genetically identical mice are a mainstay of mammalian genetics research, permitting many different scientists around the world to study the same biomedical problems by using identical strains of mice. The first inbred strains of mice were developed by Dr.
By using mouse models that have been discovered as natural mutations or developed through advanced genetic engineering techniques, scientists can determine the functions of disease-causing genes and evaluate potential therapies and cures for human ailments such as cystic fibrosis, AIDS, epilepsy, diabetes, Huntingdon’s disease, atherosclerosis, glaucoma, hypertension, and Down syndrome. Knowledge of the location and function of mouse genes can be correlated with defective human genes that cause disease. Mice and humans suffer from many of the same diseases and have similar genes and gene locations.
Little was a genetics pioneer who recognized that the study of hereditary characteristics in mice could help solve human health problems. Jackson, head of the Hudson Motorcar Co., a prominent summer visitor to Bar Harbor who helped fund the facility.ĭr. The new Laboratory was named for Roscoe B.
Little left Michigan in 1929 to fulfill his dream of building a year-round genetics research institution in Bar Harbor. He continued the popular course after joining the University of Michigan as president in 1925. Little started a summer field course for the university’s biology students amid the coastal splendor of Bar Harbor. In 1924, during his tenure as president of the University of Maine, Dr. The Jackson Laboratory was founded by Harvard-trained geneticist Clarence Cook Little.
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